Biofilm Management In Poultry

Biofilm Management In Poultry

Water is essential in controlling body temperature, supports the immune system, assist in food digestion, and aids in the processing and elimination of body wastes. Regardless of procurement of water, another concern is contamination of water inside the watering systems through a substance called “BIOFILM. It occurs when bacteria attach to the pipe walls in a drinking system, creating a sticky substrate.

Biofilms are commonly defined as attached bacterial colonies of either single or multiple species, encased in an extracellular matrix.

Biofilms support the survival of bacteria in suboptimal conditions and increase resistance to disinfectants, antimicrobial, and antibiotics. To date, it is estimated that 99% of bacteria can grow in biofilms, and it is suggested that for the majority of bacteria, biofilms are the normal mode of existence.

Plant essential oils like Thyme, Eucalyptol, Clove, Citronella, etc. Have been used for hundreds of years as natural medicines to combat a multitude of pathogens, including bacteria, fungi, and viruses. Several essential oils confer antimicrobial activity by damaging the cell wall and membrane, leading to cell lysis, leakage of cell contents, and inhibition of proton motive force.  In addition, there is evidence that they effectively kill bacteria without promoting the acquisition of resistance.

A blend of all such essential oils is HERBOFLOXIN”-This micro emulsified system;

  • The target zone for Herbofloxin is the gut; it has an antimicrobial effect in the gut due to which there is no biofilm formation.
  • It improves the number of good bacteria in the gut and simultaneously reduces the pathogenic bacteria. This action of Herbofloxin in turn provides a natural growth promoter effect in Poultry.
  • Herbofloxin is freely soluble in water and target species include Salmonella, E. Coli, Campylobacter and Clostridium

Poultry Feed Supplements Manufacturers and Suppliers in India – Vinayak Ingredients India Pvt Ltd

5 Tips To Combat Bio Aerosols In Poultry

Combat Bio Aerosols In PoultryAerial pollutants in confined animal houses are widely recognized as detrimental to the respiratory health of animals kept in these facilities. Primary and opportunistic microbial pathogens may directly cause infectious and allergic diseases in farm animals, and chronic exposure to some types of aerial pollutants may exacerbate multi-factorial environmental diseases. The key pollutants recognized in the airspace of livestock buildings are particles, including dust, micro-organisms and their toxins, and gases such as ammonia, carbon dioxide and more than 100 trace gases such as volatile fatty acids. Under commercial production conditions the airborne particles will contain a mixture of biological material from a range of sources, with bacteria, toxins, gases and volatile organic compounds adsorbed to them. Hence, a more descriptive term for these airborne particles is bio-aerosol. Their sizes can range from aerodynamic diameters of 0.5 to 100 µm.

How are bio-aerosols formed?

Under commercial production the airborne particles will contain a mixture of biological material from a range of sources. The chickens produce large amounts of dust as a result of epithelial desquamation, as well as from feed, manure, faeces and litter (Matković et al., 2009). This dust consists of a variety of airborne particles of biological origin, i.e. Bacteria, fungi, endotoxins (lipopolysaccharide, LPS) of Gram-negative bacteria, 1.3-beta-glucan of fungi, fungal spores and mycelium fragments. Hence, a more descriptive term for these airborne particles is bio-aerosol in which the microorganisms can occur either as liquid droplets or as dry particles.

To prevent this problem in poultry, Vinayak Ingredients has introduced a very effective product called “ESSENTIOLITT POULTRY”. Essentiolitt Poultry is a blend of essential oils which works as a poultry sanitizer and reduces the formation of Bio-aerosols. Its features are as below:

  1. 50% reduced respiratory diseases.
  2. It posses potential as natural agents for airborne bacterial activity inhibitors.
  3. They are ecological products for insect pest control.
  4. Reduction in mortality of birds due to severe respiratory problems.
  5. It is acting as a Bio-security in Farms.

Poultry Feed Supplements Manufacturers and Suppliers in India – Vinayak Ingredients India Pvt Ltd

Dimension of Water for Poultry Birds

Dimension of Water for Poultry Birds - Vinayak IngredientsWater management is the most critical components in a top-performing broiler flock. In high performing flocks, at around 21˚C, cutting edge broilers by and large will consume 1.8 to 2 times more water than feed, in weight. Water consumption will change, contingent upon ecological temperature, feed quality and bird health:

  1. Water consumption increases by 6% for each expansion in 1˚C between 20-32°C.
  2. Water consumption increases by 5% for each expansion in 1˚C between 32-38°C.
  3. Feed consumption diminishes by 1.23% for each expansion in 1˚C over 20°C.

Any considerable change in water utilization should be researched as this may show a water leak, health issues or feed problem. A drop in water consumption is frequently the primary marker of a flock issue. To assess flock performance legitimately we have to know how much water birds are consuming each day.

Large portions of today’s high performance broilers are being brought up in housing built for the broiler of the past. There are numerous alternatives used to guarantee a water volume/stream will address bird issues at high pinnacle request times. Advanced water meters associated with the house controller can screen water consumption on a 24-hour premise as well as in distributed time increases amid the day. This data can figure out whether our water system is keeping up at basic ‘appeal’ times, as when the lights go ahead after a dull period. Knowing this can be extremely useful in finding performance issues on a ranch, particularly one with huge, multi-houses.

The temperature of the water that birds are drinking should also be considered. The perfect water temperature ought to associate with 10-14˚C originating from the source. Water consumed by the birds should not be over 30˚C. In the event that this happens the drinking system ought to be flushed intermittently to look after cooler, fresher water.

Along with temperature and accessibility the quality of water offered to chickens should be considered for proper growth of Broilers. The quality of water depends on several factors such as the presence of bacteria and other microbes, PH, Level of minerals etc. Disinfectants like Chlorine are widely used in the poultry industry for disinfection of water, but it has many disadvantages such as carcinogenicity, pH dependent activity, highly corrosive and irritating substance. To avoid such problems and to improve performance of broilers Vinayak ingredients has launched an excellent product Herbofloxin which is a blend of essential oils effective as Non- antibiotic growth promoter. It is used to replace disinfectants, antibiotics and acidifier used for growth promotion in water.

MOA of Herbofloxin : – It is a micro emulsion when mixed with a water forms nanoemulsion making it easier to penetrate bacterial cell wall and disrupt it. It is stable at 5 to 45 degree Celsius temperature and has long shelf life.

The advantages of Herbofloxin are as follows:-

  • More than 10% improvement in weight gain
  • Chlorine free meat
  • Pathogen free meat
  • No antibiotic residue
  • Carcass sanitizer
  • Litter improver

Poultry Feed Supplements Manufacturers and Suppliers in India – Vinayak Ingredients India Pvt Ltd

Is It Necessary To Premix?

Premix in livestock feed - Vinayak IngredientsA premix is a blend of minerals, vitamins, feed supplements and diluents. The premix business is charged of the obligation of assembling a fantastic premix reliably, effectively and monetarily. The principle objective in feed mixing is to guarantee that an animal gets the majority of its figured supplement remittances consistently. Most sustain producers utilize the coefficient of variation (CV) to gauge blender execution and blend consistency. The CV is characterized as 100 * standard deviation/mean. A 5% CV is the business standard for generally fixings. An ingredient mix CV of 5% grants that an animal gets no less than 90% of its planned dietary stipends 95% of the time. Be that as it may, the size of an adequate CV will change, contingent upon the logical accuracy for measuring the fixing and the fixing proportion in the eating routine. The CV for a fixing test (repeatability of the explanatory system) out to be not exactly the wanted CV for blender proficiency. With respect to ingredient ratio, the lower the ingredient concentration in the mix, the higher the CV.  Hence, the CV is generally higher for follow mineral, vitamins and medications in light of the fact that their fixing proportions are low (under 1:10,000).

A quality premix can be made just through a stringent quality affirmation program and current great assembling rehearses (cGMP). Quality affirmation is a proactive, persistent framework for observing reproducibility and dependability of an item. It incorporates all the activities undertaken to guarantee foreordained benchmarks of a quality premix. Good manufacturing practices cover covers all the areas of the production process like staff, offices, crude materials, quality affirmation checks, stock control, preparing, blending, packaging and conveyance.

Guidelines for feed formulation

1) Premix : Premix micro ingredients, for example, antibiotic growth promoters, vitamins, and minerals with a reasonable diluent before their consideration in a supplement. Diluents serve to dilute the micro ingredient and consequently encourage the rate of blending. Diluents ought to be dry with a specific end goal to allow a more uniform scattering of individual miniaturized scale fixing particles. Dampness must be maintained a strategic distance from as it might bring about entertainment and bunching (hygroscopic mixes, for example, urea are not appropriate diluents). Nonetheless, it can be preformed all the more effective and proficiency by method for a small portable cylinder mixer (cement mixer). Defensive apparel, gloves and clean veil ought to be worn when handling micro ingredients.

2) Supplement : This supplement will contain the premix, an appropriate Carriers, and the remaining minor dry ingredients in the diet routine including minerals, urea, and supplemental protein sources. Carriers are feed ingredients which join with the small scale fixings in the premix to change their physical attributes. By adsorbing to the carrier, the fine particles of the micro ingredients are permitted to move all the more quickly and consistently through the blender. This quick development of micro ingredients through the blend is vital to guarantee satisfactory dispersion before the addition of molasses. The carriers ought to have physical properties practically identical to ground grain or oil seed dinners. For sure, both of these might be utilized as carriers. Be that as it may, the absorptive properties of ground grain and oilseed suppers are low. This constraint might be overcome by first consolidating 2% fat to the ground grain or oil seed feast before mixing with the premix. In preparing the supplement, first include the carrier, and then include other major ingredients until they achieve the focal shaft line, then include the premix and other minor ingredients, lastly include the remaining major ingredients.

3) Finished feed : Finished feed might be prepared as follows:

  • Include the grain portion of the diet to the blender
  • Add the dry supplement to the center of the blender (if possible, include supplementing the inverse end of the blender to where the feed is released
  • Permit feed to blend for at least 1 minute
  • Add forage part of the diet
  • Add fat segment of the diet
  • Add molasses of the diet
  • Permit to blend for the time determined in the blender.

4) Adding Molasses : Molasses is a typical ingredient in diet formulation. However, it is very viscous and this introduces a few issues in feed mixing. Surely, if added to the diet despicably it can bring about marked increments in the CV of the micro ingredients. Dark strap molasses are especially viscous. The proficiency of mixing dark strap molasses with other dietary fixings will be improved in the event that it is initially weakened with water. The consistency of molasses is notably diminished by warming. Molasses ought not be warmed to temperatures in abundance of 43 degrees Celsius, except for very short periods of time, as this may cause carmelization.

Here are some of the benefits of premixing, Accuracy of the weighting of the micro-ingredients

Micro-ingredients would require a much higher precision of weighting than macro-ingredients. That would request adjusted hardware that ought to be committed and set up particularly for micro-ingredients

Savings of blending time

As specified over, the preparation of premixes can decrease the preparing time. In fact, the weighting of the micro-ingredients can be extremely tedious and it would be more profitable to sort out this procedure in parallel with the preparation of the macro-ingredients.

Reduction of cross contamination

The addition of diluted micro-ingredients into the system will leave lower traces than if the same micro-ingredients were incorporated pure. Also, it is simpler to clean up the premixing equipment because of its smaller size and easier access.

Poultry Feed Supplements, Cattle Feed Supplements, Swine Feed Supplements, Aqua Feed Supplements Manufacturers and Suppliers in India – Vinayak Ingredients India Pvt Ltd

The Science of Feed Formulation

The Science of Feed FormulationFeed formulation requires top to bottom information of animal nutrition, especially the supplement necessities and the nutritional composition of the animal feed. It requires nutritionist with good knowledge of using certain proportions of some ingredients that effect on problems such as free flow through the mill, pellet quality of the diet, digestion of the animal feed or total gut well being of the animal.

Feed industry worldwide use 4 basic steps to produce animal feed.

  1. Receiving raw materials from suppliers.
  2. Generating a feed formula based on previous authentic research.
  3. Blending all the ingredients together to prepare feed.
  4. Packaging and labelling feed to be shipped for commercial or retail purposes.

Quality control is an arrangement of the methodology followed to guarantee the quality of a product and all factors involved. Quality assurance starts with an examination of incoming ingredients. Damage by heat, molds, climate, insects, adulterant and contaminants can be detected by trained technical supports. Blending quality can likewise be assessed quickly. The presence or absence of micro ingredients, minerals and vitamins are established by observation or by micro spot-testing.

Laboratory testing is a critical part of any quality control program since it quantifies particular segments of a feed/ingredient sample to guarantee that it meets quality determinations. Tests include physical, chemical, biological and other electronic measurements to determine the quality of product in contrast with a prescribed standard.

Liquid feed is used in the dairy industry to feed cattle and provide a well-balanced mixture of nutritional supplements in a molasses base, which can be distributed in a feed taken or added to another form of feed, is that the proteins promote the probiotic microorganism in the rumen, which contribute to the breakdown of fiber and forage.

Feed manufacturers must follow regulations represented by the U.S. Food and Drug Administration. FDA is in charge of the regulation of feed and implementation of policies through the state government and The Association of American Feed Control Officials. Various feed certification programs—such as the American Feed Industry Association’s Safe Feed/Safe Food Certification Program — are likewise accessible for additional compliance and regulation.

Poultry Feed Supplements, Cattle Feed Supplements, Swine Feed Supplements, Aqua Feed Supplements Manufacturers and Suppliers in India – Vinayak Ingredients India Pvt Ltd

Micro Emulsions in Poultry

Micro Emulsions in PoultryMicro emulsions in Poultry are dispersion’s of oil and water with an emulsifier. They are clear, thermodynamically stable, isotropic liquid mixtures. They are super solvents which improves stability and thermodynamic activity of formulation. Micro emulsions are beneficial to be used because it increases the efficacy of the formulation allowing dose reduction. The average particle size of micro emulsion is 0.1 micrometers which helps in increasing the inter facial area, thereby allowing active ingredients to get released easily. In poultry, micro emulsions are designed to include natural essential oils cell wall which in turn binds to mycotoxins to protect animals against mycotoxosis.

Vinayak Ingredients have introduced micro emulsion which is an alternative to antibioticsnamed as Herbofloxin. It is of natural origin prepared from essential oil of syzygium, citronella, thymus, eucalyptus. Herbofloxin has a particle size less than 0.1 micrometer which makes it easily soluble in water. It maintains poultry gut’s pH-6.5 to 6.7 which is slightly acidic. As it is a micro emulsion it has better dispersion in water, stable at 45 degree Celsius temperature and has a longer shelf life. All these factors make it safe to be consumed by poultry without having any side effects which are otherwise usually caused by using antibiotics. Herbofloxin is the natural replacer for antibiotic growth promoters.

Mechanism of action : Herbofloxin being a micro emulsion when mixed with water forms nano emulsion due to which particle size decreases further, making it easier to penetrate the bacterial cell wall and disrupt it. Disruption of cell wall leads to killing of bad bacteria such as Escherichia coli, Campylobacter, Clostridium and Salmonella. Thus, it acts like a bacteriostatic. It also acts as an anti-inflammatory by improving mucin coverage, which is a first line of defense in poultry.

Herbofloxin as a micro emulsion replaces antibiotics such as tetracycline’s, fluoroquinolones, amino glycosides and selectively modulates poultry gut to promote the beneficial microflora.

Poultry Feed Supplements Manufacturers and Suppliers in India – Vinayak Ingredients India Pvt Ltd

Poultry Gut Microbiome

Poultry Gut MicrobiomeThe microbiome of the gastrointestinal (GI) tract of poultry is very diverse yet relatively stable in a dynamic state. The poultry (e.g. duck, chicken and turkey) GI tract consists of cloaca, colon, cecum, small intestines (duodenum, jejunum and ileum), gizzard, proventriculus, crop and esophagus. The GI tract of the poultry is much shorter than that of mammalian animals. But it contains highest bacterial abundance and diversity. The bacteria found in the intestine mostly include Escherichia coli, Lactobacillus, Bacteroids, Eubacterium, Peptostreptococcus, Propionibacterium as predominant organisms. Other group of micro organisms such as anaerobic, gram-negative cocci, facultative anaerobic cocci and streptococci are also found in the GI tract. In this article we briefly discuss the factors affecting the poultry gut micro biome and its importance for poultry nutrition.

Microbiome and Host

Many intestinal bacteria hydrolyze carbohydrates to simple sugars which are further fermented to short chain fatty acids (SCFA) (viz., butyrate, propionate and acetate) by other intestinal bacteria. The SCFA are utilized as a source of energy and carbon. Gut bacteria also contribute to host nitrogen metabolism. These bacteria metabolize uric acid to NH3, which is utilized by the host to synthesize a few amino acids such as glutamine. Gut micro biome of poultry may also serve as a source of vitamin to its host. Mucins secreted by goblet cells of the gut are important source of carbon, nitrogen and energy for some commensal and pathogenic bacteria. Gut micro biome also has impact on intestinal morphology of poultry. One such effect is evident when birds raised on a conventional diet show shorter intestinal villi and shallow crypts with low load of bacteria. However, dietary supplementation of probiotic organisms increases villus height: crypt depth ratio in ileum of broilers.

Microbiome and Immunity

The first line of defense mechanism in the inner surface of avian gut is the gel-like mucus layer formed from mucin glycoprotein produced by the goblet cells. The mucus layer prevents the intestinal pathogens from penetrating into intestinal epithelium. The disruption of the mucus layer is probably due to the severe necrosis of the intestinal mucosa which results in vast shedding of goblet cells. Production of beta-defensin is another important strategy present on the intestinal epithelial surface. Βeta-defensin are produced by avian macrophage, heterophils and epithelial cells that kills various intestinal pathogens by disrupting cell membrane permeability. In birds, the cell mediated immunity (T and B cells) can be found in dispersed areas (lamina propria and epithelium) and in more organized lymphoid tissues (Payer’s patches and bursa of fabricius).

Microbiome and Diet

Diet has great potential to modulate the host digestion and nutrient absorption. Wheat, barley or rye-based diets have more impact on the gut micro biome. These diets contain high levels of water-soluble, indigestible, non-starch polysaccharide that favor necrotic enteritis. Excessive non-starch polysaccharide leads to rise in digesta viscosity, decreased digesta passage rate and a decline in nutrient digestibility. Another potential diet ingredient, soyabean is used as a source of protein to promote the growth lactobacilli population and reduce the number of coliforms in cecum of poultry. Some of the gut micro organisms are also influenced by dietary fat source. Dietary enzymes such as xylanase and beta-glucanase, increase intestinal lactic acid bacteria(LAB) and decrease the population of adverse and pathogenic bacteria such as E. coli. Dietary supplementation with xylanase and beta-glucanase protects against necrotic enteritis as the enzyme breakdown the non starch polysaccharide in the diet and reduce the digesta viscosity. Plant derived trans-cinnamaldehyde and eugenol are effective in reducing S. enteritis colonization in 20-d old broiler chickens. Others such as blend of essential oils, containing thymol, carvacrol, eugenol, curcumin and piperin reduce the colonization and proliferation of such pathogens. Antibiotic growth promoter (AGP) is another feed additive used to improve feed efficiency, increase animal growth and maintain animal health. The inclusion of AGP in poultry diet reduces the incidence of disease and promotes better performance of the birds by inhibiting the growth of enteric pathogens. However, due to rising antibiotic resistance among the pathogens, the use of AGP has been prohibited. The proliferation of the bacteria present in the gut can be increased by the ingestion of prebiotics.

Prebiotics are polysaccharides such as galatosaccharide (GOS) and fructosaccharide (FOS).

GOS favors the growth of Bifidobacteria in the GI tract of broiler chicken.

Competition for nutrient and attachment site

The GI tract of newly hatched chick is sterile, but is immediately colonized by surrounding organisms. Over the period of time, normal colonization and succession of gut micro biome takes place in healthy adult poultry’s intestine. The GI tract serves as an ideal habitat for micro organisms however, due to limited space and resources; there is competition among organisms for nutrient resources. Some bacteria produce bacteriostatic or bactericidal substances to kill its competitors. The LAB ferment carbohydrates to organic acids and inhibits the growth of certain pathogens such as E. coli and Salmonella by reducing the pH of the gut. Certain bacteria such as Enterococcus sp., Pediococcus sps., Bacillus subtilis also produce antimicrobial agent called bacteriocins to selectively inhibit the growth of other bacteria. However, pathogens are adapted to new environment very fast mediated by a process such as conjugation, transformation and transduction. Providing probiotics (live microbial feed supplement) benefits the host through the following mechanisms:

(1) Inhibiting the growth of pathogenic bacteria from colonizing and proliferating in the gut through competition for nutrient and attachment site

(2) Production of bacteriostatic and bactericidal substances against pathogens

(3) Enhancing gut barrier function and

(4) Enhancing host immunity.

Poultry litter microorganisms influence gut microbiome

Chickens are in constant contact with the micro organisms from the surrounding environment. The poultry litter usually harbors a complex microbial community. Reuse of poultry litter commonly practiced by poultry farmers to reduce produce cost, influences chicken guts micro biome. The reused litter may also harbor disease-causing micro organisms from the previous flock and thus serves as a source of pathogens to the subsequent flock.

Conclusion

The gut represents an essential microbial ecosystem that lives in symbiosis with the host. The development of GI micro biome plays a crucial role in the nutrition, health and growth of the chicken. Thus further research on the intestinal micro biome of the poultry can potentially provide us more knowledge to improve management of poultry diseases, antibiotic resistance and better control of colonization and spread of human pathogens.

Poultry Feed Supplements Manufacturers and Suppliers in India – Vinayak Ingredients India Pvt Ltd

Antibiotic Alternative & Growth Promoter

Antibiotic Alternative Growth Promoter - Vinayak IngredientsAnimal diseases have a large impact on the economy of the livestock industry having total estimated global losses up to $2773 million annually. The disease may have a direct effect on performance through decreased production of milk, wool, or eggs, reduced fertility, delays in reaching maturation of reproductive system, decreased draught power or decreased weight of cull animals. These epidemics have the direct effect on farmers, consequently affecting agricultural sector and the national economy.
There is no doubt in the fact that certain dietary antibiotics have been playing a pivotal role in promoting good growth and health in animal production and feed conversion efficiency. However, the emergence of drug resistance among pathogens and public concerns of antibiotic residues in meat has led the European Commission (EC) to draw a critical decision to ultimately ban (January 1st, 2006), the marketing and application of antibiotics growth promoters (AGP) as feed additive (EC Regulation No. 1831/20031). This verdict was taken on the basis of the precautionary principle: ‘Where there are threats of serious or irreversible damage, lack of full scientific certainty shall not be used as a reason for postponing cost-effective measures to prevent environmental degradation’ (Principle 15 of the Rio Declaration, 19922).

Will the ban on antibiotic growth promoters in animal feed have the desired effect of reducing the overall level of antimicrobial use in animals? At the moment, this looks to be highly unlikely, as statistics continue to show a sudden rise in the use of AGP used for remedial purposes, even though there is a significant reduction in the usage of antibiotic growth promoters. In countries such as the USA the use of AGP in the poultry industry has been formally declined. This has led to increase in FCR and rise in the incidence of necrotic enteritis. Necrotic enteritis (NE) is an acute infection caused by Clostridium species. This is characterized by excessive dehydration, severe intestinal tissue necrosis with an increase in death rate. Such sick birds that do not have access to appropriate treatment are likely to carry much heavier loads of bacteria at the time of processing. The escalating usage of treatment antibiotics is essential for the effective control of prevalent diseases such as coccidiosis and necrotic enteritis in poultry, diarrhoea and inflammation of ileum in pigs, which have serious consequences and may badly affect production performance. From a veterinary point of view, withdrawing AGPs and in-feed anticoccidials may open the door to more enteric pathogen invasion.
In light of recent publicity surrounding the use of antibiotics by livestock and poultry industries, there are reports claiming to be alternatives to antibiotics which have the direct or indirect effect on microflora. Ideally, the alternatives to AGP should function in a same way as growth promoters without hindering its beneficial effects i.e.

(1) By reducing the amount of toxins and other metabolites produced by gram-positive bacteria.

(2) By increasing the intestinal wall permeability thereby improving absorption of nutrients.

(3) By blocking enzymes secreted by the pathogens thereby reducing the incidence and severity of sub-clinical infections.

Few of the most widely used alternatives for AGP along with their mode of action is briefly discussed:

Organic acids
Organic acids are widely distributed in animal tissues formed through catabolism of carbohydrates by microbial fermentation mainly in the caecum of the poultry intestine. The antibacterial nature of organic acid is mainly due to the low pH. The environmental pH change affects the dissociation of the acid which enhances the antimicrobial effect. The dissociated form of acid molecules freely diffuses through the semi-permeable membrane of microorganisms into the cell cytoplasm. Once in the cell, the acid molecules will disrupt the cell enzymes and nutrient transport mechanism.
To read more: Adams, C., 1999. Nutricines: Food Components in Health and Nutrition. Nottingham University Press, UK.

Probiotics and Prebiotics
Probiotics are mixed cultures of live bacteria which improve the growth and characteristics of the indigenous microflora thereby benefiting the host’. The most well-known group of probiotics is lactic acid bacteria. Most of the probiotic strains produce specific metabolites such as hydrogen peroxide, secondary metabolites, and organic fatty acids. It also stimulates the immune system while interacting with the various receptor sites. On the other hand, Prebiotic are non-digestible feed ingredients with selective effects on the intestinal microflora. The mechanism of action of prebiotics as an alternative is dependent on the nature of the compound. They are feed ingredients that improve the activity of the gut microflora because of selective stimulation of the growth or metabolic activity of a limited number of intestinal micro-biota species, such as Bifidobacteria and Lactobacillus sp. Thus, they may have a similar mechanism of action as probiotics.

Herbs and essential oils
It is not an unknown fact that the herbs are used for beneficial therapeutic properties derived from their specific bio-active components. Most of the bioactive compounds of the plant are mostly secondary metabolites such as terpenoids (mono- and sesquiterpenes, steroids, etc.), phenolics (tannins), glycosides and alkaloids (present as alcohols, aldehydes, ketones, esters, ethers, lactones, etc).Essential oils are concentrated products with very strong aromatic fragrance produced by  these secondary metabolites. The mechanism of action of bio-active compounds on chemical constituents, biological factors and so on. Bio-active constituents derive from plants play important role in inhibiting the bacteria by inactivation of the protein, loss of function, neutralizing free radicals. The study of microbial activity of essential oils and other bio-active compounds on micro-organisms still remains area of future research.

CONCLUSION
Alternatives for AGPs are only of practical significance which improves animal performance as compared to AGPs.  Microflora stimulating and immunomodulatory compounds have potential and are used as feedstuff of feed additives. Acids, probiotics, prebiotic and herbs or essential oils are some examples of different naturally available products which are used as alternatives for AGPs. Within each product class, numerous other products are available in the market, of which some products are potentially good, for others the efficacy is not clear. Hence, this brings us to a point to describe the mechanism of actions of these useful vital compounds in a whole scientific manner that meets high grades for AGP alternatives for poultry.

Poultry Feed Supplements, Cattle Feed Supplements, Swine Feed Supplements Manufacturers and Suppliers in India – Vinayak Ingredients India Pvt Ltd