What is the role of Hepatoprotectant in poultry?

What is the role of Hepatoprotectant in poultry?

The liver is the central laboratory of a chicken’s body. It is essential that this organ is kept in an excellent condition in order to maintain a healthy bird. Understanding the metabolic function and causes of disruptions in liver functions helps us to provide the birds with the right feed and health treatment. The liver contains great functional reserve capacity, which is very important in domestic animals subjected to high production requirements.

What are the functions of liver in poultry?

The liver in a chicken has several significant functioning including; bile secretion, detoxification, metabolism of carbohydrates, lipids and proteins, as well as several other metabolic functions.

Liver diseases: Important damage can occur before clinical signs become apparent. The clinical silence of the hepatic lesions is due its significant reserve of functional capacity, its complex and its extraordinary capacity of regeneration. Several syndromes are recognized in the poultry and a few of them are;

Hepatoencephalopathy: medical condition characterized by neurologic symptoms caused by intoxication of the brain by products of protein digestion, namely ammonia.

Hemochromatosis: it is a disease of excessive storage of Hemosiderin (iron-containing pigment) in various body tissues.

Fatty Liver Syndrome: this condition occurs primarily in birds kept in cages, but has also been recognized as a less significant problem in birds kept on litter. It is associated with birds fed high energy diets and the first sign of the syndrome is an increase in mortality of the flock with birds in full production being found dead with pale heads.

Need for HEPATOPROTECTANT:

To overcome effects of these conditions in poultry there is a need for a hepatoprotectant/ liver tonic which is a combination of lipotropic agents, liver stimulants, antioxidants, mould inhibitors and toxin binders as a complete liver tonic.

Such a unique combination is KiFAY which apart from being an amino acid optimizer also has as a hepatoprotectant effect in poultry as follows:

  1. A ready source of amino acids for hepatic regeneration
  2. Better utilization of fats
  3. Facilitate detoxification and liver cell rejuvenation
  4. Natural defence against free radicals causing cell damage, including that of liver.
  5. Reduction in mycotoxins formation   

An overview of Feeding Chickens for increasing Performance and Productivity

Overview of feeding chickens

An essential part of raising chickens is nourishing – feeding makes up the significant cost of production and great nutrition is reflected in the bird’s performance and its productivity.

Feeding Options

The most advantageous method for feeding chickens is with a well balanced pelleted ration, regardless of whether the birds are restricted inside or permitted to range outside. Most diets contain corn for vitality, soybean meal for protein, and vitamin and other mineral supplements. Commercial rations regularly contain antibiotics to promote and enhance development, coccidiostats for battling coccidiosis, and mold inhibitors. In any case, it is possible to acquire unmedicated encourage check nourish marks to check whether they contain feed additives. In the industry, feed is pelleted so the bird can eat more at one time. Chickens are nibblers and make visit to the nourish trough for little dinners, which requires vitality. Pelleting lessens the measure of vitality required for a feathered creature to bolster.  Distinctive rations are frequently utilized, depending upon the production stage of the bird. Starter rations are high in protein- an expensive feed ingredient. However, grower and finisher rations can be lower in protein since older birds require less. Access to clean water is important. Levels of total dissolved solids over 3000 ppm in the water can meddle with poultry wellbeing and production.

Home-mixed Rations

Poultry feed ingredients incorporate energy concentrates, for example, oats, corn, grain, wheat, sorghum, and milling by-products. Protein concentrates incorporate soybean meal and other oilseed meals, cottonseed meals, animal protein sources, grain legumes, for example, dry beans, peas, and alfalfa. Grains are generally ground to enhance absorbability. Since protein is one of the most expensive feed ingredients, the industry utilizes focused on rations and decrease the measure of protein in the eating routine as the chickens develop; notwithstanding, it may not be cost-effective to have diverse eating diets for starters, growers, and finishers. Vitamin pre-mix is normally included however might be diminished by utilizing horse feed. Different plants also give vitamins in their leaves, hulls, and wheats. Fish oil can give vitamins A and D. Yeast gives a ration of the B vitamins. UV light is a decent source of vitamin D for going chickens. Trace mineral is normally added to poultry diets, yet different sources can give minerals. Meat and bone meal is a fantastic source of minerals, especially calcium and phosphorus, and additionally being a decent protein source. Probiotics are once in a while given to chicks during placement and before transportation.

Certified Organic Diets

Home-mixed diets are especially valuable to certified natural poultry producers. In spite of the fact that pre-mixed natural poultry rations are accessible for procurement, they can be costly and maybe ought to be dispatched from long distances.

Feed Additives in the Diet

Feed additives are added to improve the efficiency of broiler growth, laying capacity of layers, prevent diseases and to promote health. The feed additives used in poultry diet include amino acids, vitamins, antimicrobials, pH control agent, and enzymes. Protein and amino acids form an important building block in poultry nutrition. The quality of protein is graded by its illeal amino acid digestibility, the higher the digestibility the better is the ingredient as a protein source. Deficiency of essential amino acids result in retarded growth or reduced egg size or reduced egg production.

To help the industry in balancing the protein turnover and amino-acid optimization of the birds, We at Vinayak Ingredients (India) Private Limited introduces one of our niche product with a brand name; KiFAY”- an Amino Acid Optimizer.  It is an all in one product for optimizing your poultry feed and production.

MOA OF KiFAY: It improves the availability of insulin receptors which are potential binding sites for IGF-1 and thus potentiating the action of IGF-1 resulting in improved  ileal digestibility of various amino acids in the feed and also improves the their uptake from blood. Thus improved amino acid accretion from blood results in better protein turn over. It also increases the efficacy and production of IGF-1 by stimulating insulin production resulting in increased bio-availability of IGF-1 in the liver.

The reason why we should use KiFAY:-

  • In broilers it increases the weight by improving feed conversion ratio (FCR) and protein utilization.
  • In layers KiFAY enhances the quality and other parameters of egg like;
  • Egg shell weight by 9-10%, Egg shell thickness by 15%, Egg weight 8%, Egg length by 15-16%, Egg width by 32-33%
  • It also reduces faecal nitrogen deposition by improving protein turnover.
  • It acts as a hepatoprotectant by inhibiting free radicals causing damage to the liver cells.
  • It  optimizes immunomodulation by enhancing Gut associated lymphoid tissues (GALT)

Thus KiFAY acts as a performance enhancer in poultry.

IS GOAT NUTRITION OPTIMAL?

Goats are animals belonging to the category of the browser and prefer eating brushy plants and some other woody, weedy plants found on the ranges. Nutritional requirements of goats are determined by their age, sex, breed, production system (dairy or meat), body size, climate, and physiological stage. The Feeding strategies also play a vital role and help them to meet the energy, protein, mineral, and vitamin needs depending on the condition of the goats. Goats do not depend on intensive feeding systems except for some supplemental feeding during growth, lactation, pregnancy, and winter. Goats belong to the small ruminant group; this group utilizes protein most efficiently provided with a supply of amino acids that also matches tissue requirements and is utilized for growth in ruminants. The amino acids composition of body protein helps to determine the balance of amino acids required for growth in mammals. The ideal protein is a perfect ratio among individuals all amino acids and nitrogen required for optimal performance.

To help the livestock industry in balancing the protein turnover and amino-acid optimization of ruminants, We at Vinayak Ingredients (India) Private Limited take our privilege to introduces one of our niche product with a brand name; KiFAY”- an Amino Acid Optimizer.  It is an all in one product for optimizing the overall performance and productivity of goats and other meat producing animals,

MOA OF KiFAY: It improves the availability of insulin receptors which are potential binding sites for IGF-1 and thus potentiating the action of IGF-1 resulting in improved ileal digestibility of various amino acids in the feed and also improves the their uptake from blood. Thus improved amino acid accretion from blood results in better protein turn over. It also increases the efficacy and production of IGF-1 by stimulating insulin production resulting in increased bio-availability of IGF-1 in the liver.

The reason why we should use KiFAY:-

  • It improves hair and skin quality of the flock.
  • Enhances lean meat production.
  • Also it improves the digestibility of the food helping in more protein synthesis and weight gain.
  • It improves the milk quality and increases milk production rate
  •  It acts as an immunity enhancer.

Thus KiFAY is an all in one performance enhancer!!

Essentiality of good management practices in livestock production

Livestock industry is an important component of the agricultural sector of any country producing meat, eggs, beef, pork, eggs and other quality products of animal origin. This industry plays a vital role in market development and use of technology. Food safety is universally recognized as a public health priority. It requires a holistic approach, from production to consumption. Various aspects of animal production are at risk from biological, chemical and physical agents. These agents canenter food-producing animals and animal products through a wide variety of exposure points in the production, with high potential risks for the consumers. Therefore it is essential that Good Management Practices are followed in the meat production to address these hazards. Following are the recommended Good Practices that should be followed on the farm;

Sanitation and hygiene
All movable equipments like feeders, waterers and hovers should be removed from the house, cleaned and disinfected. The interior as well as exterior of the house should be cleaned under pressure. The house should be disinfected with any commercial disinfectant solution at the recommended concentration.

Brooder Management
Brooder house: It should be draft-free, rain-proof and protected against predators. Brooding pens should have windows for adequate ventilation. Availability of dust particles in the environment irritates the respiratory tract of the chicks. Also dust is one of the vehicles for disease transmission. Presence of more moisture in the environment causes ammonia fumes which irritate the respiratory tract and eyes.

Brooding Temperature: Heating is very much essential to provide right temperature in the brooder house.  Too high or too low temperature slows down growth and causes mortality. During the first week the temperature should be 95°F (35°C) which may be reduced by 5°F per week during each successive week till 70°F (21·10C). The brooder should be switched on for at least 24 hours before the chicks arrive. As a rule of thumb the temperature inside the brooder house should be approximately 20°F (-6·7°C) below the brooder temperature.

Animal Nutrition and Feeding: Meeting the requirements of livestock nutrition is extremely important to maintain acceptable performance of neonatal, growing, finishing and breeding animals. An optimal nutritional program should ensure adequate intakes of amino acids (essential and nonessential), carbohydrates, fatty acids, minerals, and vitamins by animals through a supplementation program that corrects deficiencies in basal diets.22 amino acids are needed to form body protein, some of which can be synthesized by the bird (non-essential), whereas others cannot be made at all or in sufficient quantities to meet metabolic needs (essential). Essential amino acids must be supplied by the diet, and a sufficient amount of non-essential amino acids must also be supplied to prevent the conversion of essential amino acids into non-essential amino acid. These essential amino acids must therefore be fed in order to supply the building blocks needed in the synthesis of body proteins thereby supporting growth.

Some other Farm management practices include; Litter management, Water Sanitization, Animal health management, Veterinary medicines and biological, Environment and infrastructure, Animal and product handling, etc.

We at Vinayak Ingredients Pvt. Ltd. Aim at making the livestock production free from all the major hazards for safe and healthy production and consumption of the meat. We believe in “HERBOCORE” process and our aim is to manufacture safe, eco-sustainable and cost effective solutions for the benefits of the industry”. Our wide variety of products includes;

  • “KiFAY”-an Amino Acid Optimizer. It improves the availability of insulin receptors which are potential binding sites for IGF-1 and thus potentiating the action of IGF-1 resulting in improved ileal digestibility of various amino acids in the feed and also improves their uptake from the blood. Thus, improved amino acid accretion from blood results in better protein turn over. It also increases the efficacy and production of IGF-1 by stimulating insulin production resulting in increased bio-availability of IGF-1 in the liver.
  • “HERBOFLOXIN”-Natural antibiotic growth promoter. It improves the number of good bacteria in the gut and simultaneously reduces the pathogenic bacteria.
  • “MUCOFORT”-An Advance Mucin enhancer and respiratory tonic.
  • “ESSENTIOLITT”-It is an anti-vector solution. Controls and eradicates all stages of the insects and also ensures an unfavorable environment for them to prevent re-infestation.
  • “VINTOXO”- an excellent Toxin Binder which absorbs various mycotoxins on the surface with a CEC of 35 to 45 mEq per 100gms; it is able to absorb polar as well as non-polar mycotoxins and clears it out of the system.

Maintaining protein nutrition in chickens

Necrotic enteritis in broiler chickens can be caused due to the increased
level of protein, 2-6 weeks post hatching. This is because of the over growth
of C. perfringens in the small digestive system, increasing from a typical
level of 10 4 CFU to 10 7 or 10 9 CFU per gram of digesta and causing harmful diseases.
With the increased dietary protein level, there will likewise be an increased activity of the trypsin in the small digestive system. This will, thusly, prompt to speedier arrival of coccidia from their oocytes which will lead so dynamic as to be less responsive to immunization.
In situations where such bacterial and protozoan are probably going to
prevail, it might then be advantageous, among different measures, to reduce the supply of protein and maintain it underneath the prescribed range. It is likewise important to consider the amino acid balance of the protein source to be utilized. Methionine and glycine, for instance, have been known to empower growth and establishment of C. perfringens and different pathogens in the gut.
Accordingly, the utilization of protein sources having over the top measures of these amino acids ought to be limited. Additionally, there are some protein sources, for example, cottonseed meal, raw soybean, and flax cakes, which contain varying measures of anti-nutritional factors, for example, trypsin inhibitors, gossypol, and glucosides. At the point when ingested by the bird, these components would then apply some damaging consequences for the small digestive tract, in this manner impeding
the safe mechanical assembly having nearby as well as systemic defensive capacities. Excessive utilization of such protein sources in the diet ought
to, therefore, be avoided as well.

Monitoring Chicken Feed for Enhanced Productivity and Performance

An essential part of raising chickens is nourishing – feeding makes up the significant cost of production and great nutrition is reflected in the bird’s performance and its productivity.

Feeding Options:The most advantageous method for feeding chickens is with a well balanced pelleted ration, regardless of whether the birds are restricted inside or permitted to range outside. Most diets contain corn for vitality, soybean meal for protein, and vitamin and other mineral supplements. Commercial rations regularly contain antibiotics to promote and enhance development, coccidiostats for battling coccidiosis, and mold inhibitors. In any case, it is possible to acquire unmedicated encourage check nourish marks to check whether they contain feed additives. In the industry, feed is pelleted so the bird can eat more at one time. Chickens are nibblers and make visit to the nourish trough for little dinners, which requires vitality. Pelleting lessens the measure of vitality required for a feathered creature to bolster. Distinctive rations are frequently utilized, depending upon the production stage of the bird. Starter rations are high in protein- an expensive feed ingredient. However, grower and finisher rations can be lower in protein since older birds require less. Access to clean water is important. Levels of total dissolved solids over 3000 ppm in the water can meddle with poultry well being and production. 

Home-mixed Rations: Poultry feed ingredients incorporate energy concentrates, for example, oats, corn, grain, wheat, sorghum, and milling by-products. Protein concentrates incorporate soybean meal and other oilseed meals, cottonseed meals, animal protein sources, grain legumes, for example, dry beans, peas, and alfalfa. Grains are generally ground to enhance absorbability. Since protein is one of the most expensive feed ingredients, the industry utilizes focused on rations and decrease the measure of protein in the eating routine as the chickens develop; notwithstanding, it may not be cost-effective to have diverse eating diets for starters, growers, and finishers.

NEONATAL POULTRY NUTRITION

Over the last five decades, improvements in nutrition and genetic selection have reduced the time required to produce a 2 Kg broiler within 1.7 FCR. The neonatal period is defined as the first seven days of the production cycle after hatch. It is a crucial time when the chick requires special management and nutrition. Efforts to control metabolic disorders such as ascites and leg problems have led to recommending early feed restriction during the first two weeks post-hatch. Thus, it is essential to know the effect of poultry management practices on subsequent chick development. A paper presented in the Ohio university explains the importance of the relationship of neonatal nutrition to muscle development. Muscle growth and development can be divided into two distinct periods: hyperplasia and hypertrophy. Hyperplasia is an embryonic period characterized by proliferation of muscle fiber number whereas hypertrophy is a post-hatch muscle growth that results in the enlargement of existing muscle fibers. Nutritional deprivation has a significant effect on myoblast cells. The research was conducted to evaluate the effects of an immediate post-hatch feed restriction on breast muscle formation. The increased number of nuclei in muscle fibers correlates with increased synthesis of protein and muscle fiber size enlargement. Myoblast cells are extremely responsive to the mitogenic effects of their environment, including nutrition. A 42-day length of a study conducted with feed restriction on the neonatal chickens showed a significant difference morphologically in the development and structure of the breast muscle between the feed restricted and unrestricted diet treatments. It also increased the deposition of fat in the breast muscle of the birds with the 20% feed restriction.
The Bottom Line Nutrient deprivation in the first few days after hatch may interfere with normal muscle protein development in broiler chicks. However, if you believe that flavor and juiciness follow the fat, there may
be some benefit from an early feed.

What is the effect of KiFAY on IGF-1 and protein accretion in broilers?

A comparative study was performed to investigate the efficacy of KiFAY™ as a feed additive on performance parameters, thyroid, and pancreatic hormone levels in broilers. Ninety birds (Vencobb 400) were randomly divided into three groups viz., Control (no DL-methionine supplementation), Treatment1 (containing added DL-methionine) and Treatment2 (containing KiFAY™ and without DL-methionine
supplementation). The performance parameters (weekly body weight, body weight gain, feed intake, and feed consumption ratio) were recorded and calculated during the whole study of 4 weeks.

Analysis of insulin and insulin-like growth factor (IGF1), triiodothyronine (T3), thyroxine (T4) and thyroid stimulating Hormone (TSH) were performed at the end of the study. The results show that birds on supplementation of KiFAY™ performed significantly (p<0.001) better than other treatments. The weekly body weight, body weight gain, feed in-take and feed consumption ratio improved in KiFAY™ treated birds. The study shows an increase in insulin and IGF1 levels (p<0.001) in KiFAY™ than other treatments.

Serum T3, T4 and TSH levels in the treatment2 were higher than other treatments (p<0.001). The KiFAY™ supplementation was able to improve performance with associated responses at a hormonal level in broilers.