In recent years there is growing interest in the use of feed additives with immunomodulatory properties in intensive poultry production since today’s chickens are more susceptible to diﬀerent infectious and metabolic diseases and exhibit a high mortality rate. Aer the removal of the sub-therapeutic use of antibiotic growth promoters (AGP) from animal nutrition in the European Union, the interest in natural feed additives with immunomodulatory properties have increased signiﬁcantly.
Due to the growing demand of the nutritional immunomodulators, we have designed NUCLEOVIN which provides speciﬁc nutrients to aﬀect some aspects of immune function. NUCLEOVIN is a potential immunomodulator that contains nucleotides, vitamin C and probiotics that can activate immune system responses. These bioactive components can be used either in the prophylactic/therapeutic approach or in the prevention/treatment of stress and microbial induced disorders.
Nucleotides are nature’s most important bioactive molecules that combine in a speciﬁc manner to control the biological reactions associated with all the life processes. The immunomodulatory eﬀects of nucleotides on diﬀerent types of immune responses have been conﬁrmed in numerous in vitro and in vivo experiments. They play a major role in structural, energetic and regulatory functions and are involved in almost all the advice of the cell. Because of their role in supporting and enhancing immunity, dietary nucleotides are the best alternative to trigger high performance.
Probiotics act by supporting the dynamic equilibrium of the intestinal microﬂora thereby reducing digestive problems and losses caused by nutrition. Numerous scienﬁc trials and practical studies also corroborate the positive eﬀects of probiotics.
Vitamin C is a relatively simple compound and all species of poultry exhibit the innate capacity to synthesize it in the kidneys. Inadequate biosynthesis of vitamin C is mainly due to the higher demand by modern commercial breeds under intensive conditions of management and disease control.
SYNERGY AND ECONOMIC SIGNIFICANCE
The immunostimulative eﬃcacy of nucleotides, probiotics and vitamin C has been thoroughly evaluated and successfully utilized by our company in diet supplementation. Their combination produces a greater than expected result to overcome multiple health complications. Hence, NUCLEOVIN is eﬀecve in many serious clinical situations even where multiple therapies have failed. Such a synergistic combination, with practically no side eﬀects, can also be used to treat complex poultry challenges.
This novel combination inﬂuences many essential and diverse functions in the body, both directly or indirectly and aﬀects many physiological and commercial parameters of which most commonly observed ones are given below.
Immunosuppression – Multiple components in the intensive poultry production like environmental temperature, diseases, toxicity, vaccination, forced molting or improper nutrition results in stress that eventually leads to immunosuppression.
Heat Stress – Heat exposed birds lower their feed consumption to reduce the thermogenic eﬀect, predisposing them to the disease.
Reproductive Performance – Fertility, hatchability, and egg production are severely aﬀected by insuﬃcient biosynthesis of vitamins and enzymes.
• Optimum reproductive performance – hatchability, fertility, embryo survival, and development, etc.
• Reduces immunological stress
• Improves egg shell thickness
• Minimizes toxin-related detrimental eﬀects
• Enhances vaccine performance
• Heat and disease resistance
• Reduces mortality
• Accelerates growth performance
DESIRED TIME FRAME FOR SUPPLEMENTATION
• Breeder birds: 4 – 5 weeks
• Layer birds: 2 – 3 weeks
• Chicks: First 14 days