In recent years there is growing interest in the use of feed additives with immunomodulatory properties in intensive aquaculture production. Unlike land animals, aquatic farmed animals are surrounded by a large variety of opportunistic pathogens independently of the host animal, and hence the pathogens can reach high abundance around the animal. Moreover, aquaculture species are more susceptible to different infectious and metabolic diseases and exhibit a high mortality rate. AGer the removal of the sub-therapeutic use of antibiotic growth promoters (AGP) from animal nutrition in the European Union and other countries, the interest in natural feed additives with immunomodulatory properties have increased significantly.
Due to the growing demand of the nutritional immunomodulators, we have designed NUCLEOVIN which provides speciﬁc nutrients to affect some aspects of immune function. NUCLEOVIN is a potential immunomodulator which contains nucleotides, vitamin C and probiotics that can activate immune system responses. These bioactive components that can be used either in prophylactic / therapeutic approach or in prevention / treatment of stress and microbial induced disorders.
Nucleotides are the nature’s most important bioactive molecules that combine in a specific manner to control the biological reactions associated with all the life process. The immunomodulatory effects of nucleotides on different types of immune response have been confirmed in numerous in vitro and in vivo experiments. They play a major role in structural, energetic and regulatory functions and are involved in almost all the activities of the cell. Because of their role in supporting and enhancing immunity, dietary nucleotides are the best alternative to trigger high performance. Probiotics act by supporting the dynamic equilibrium of the intestinal microflora thereby reducing digestive problems and losses caused by nutrition. Numerous scientific trials and practical studies also corroborate the positive effects of probiotics.
Vitamin C is a relatively simple compound and is a powerful antioxidant and immunomodulator for fishes and shrimps. Inadequate biosynthesis of vitamin C is mainly due to the intensive conditions of management and disease control.
Synergy and Economic Signiﬁcance
The immunostimulative efficacy of nucleotides, probiotics and vitamin C has been thoroughly evaluated and successfully utilized by our company in diet supplementation. Their combination produces a greater than expected result to overcome multiple health complications. Hence, NUCLEOVIN is effective in many serious clinical situations even where multiple therapies have failed. Such a synergistic combination, with practically no side effects, can also be used to treat complex aquaculture challenges.
This novel combination inﬂuences many essential and diverse functions in the body, both directly or indirectly and affects many physiological and commercial parameters of which most commonly observed ones are given below.
Immunosuppression : Multiple components in the intensive aquaculture production like environmental temperature, diseases, toxicity, improper nutrition results in stress that eventually leads to immunosuppression.
Water Temperature Stress : This combination helps fishes during low temperature period to enhancing digestion efficiency and thereaGer promote growth rate.
Reproductive Performance : Improvement in reproduction systems of ﬁshes and shrimps by growth of healthy brooders, proper egg and sperm formation, optimum fecundity, improved hatchability, healthy larval and fry conditions.
Larval Nutrition : Diet with NUCLEOVIN helps in fast development of embryo /larvae/ early fry stages and reduces mortality of early stages of fishes /shrimps.
Wound Healing : The collagen formation in enhanced in the body which helps in quick and optimal wound repair in fishes and shrimps.
- Enhances in immune response
- Increases intestinal absorption of minerals from plant-based foods
- Acts as an antioxidant and plays a crucial role in neutralizing free radicals throughout the body
- Reduces the effects of toxic chemicals in water and prevents the negative effects of water temperature fluctuations
- Regulates the moult phase and helps in quick formation of exoskeleton in shrimps
- Helps synthesize carnitine, adrenaline, epinephrine, the neurotransmitter serotonin, the thyroid hormone thyroxine, bile acids, and steroid hormones
- Nucleotides, Vitamin C and Probiotics
150 – 250 g per tonne of feed for shrimps.