Necrotic enteritis in broiler chickens can be caused due to the increased level of protein, 2-6 weeks post hatching. This is because of the over growth of C. perfringens in the small digestive system, increasing from a typical level of 104 CFU to 107 or 109 CFU per gram of digesta and causing harmful diseases.
With the increased dietary protein level, there will likewise be an increased activity of the trypsin in the small digestive system. This will, thusly, prompt to speedier arrival of coccidia from their oocytes which will lead so dynamic as to be less responsive to immunization.
In situations where such bacterial and protozoan are probably going to prevail, it might then be advantageous, among different measures, to reduce the supply of protein and maintain it underneath the prescribed range. It is likewise important to consider the amino acid balance of the protein source to be utilized. Methionine and glycine, for instance, have been known to empower growth and establishment of C. perfringens and different pathogens in the gut. Accordingly, the utilization of protein sources having over the top measures of these amino acids ought to be limited.
Additionally, there are some protein sources, for example, cottonseed meal, raw soybean, and flax cakes, which contain varying measures of anti-nutritional factors, for example, trypsin inhibitors, gossypol, and glucosides. At the point when ingested by the bird, these components would then apply some damaging consequences for the small digestive tract, in this manner impeding the safe mechanical assembly having nearby as well as systemic defensive capacities. Excessive utilization of such protein sources in the diet ought to, therefore, be avoided as well.