Vitamin D is a fat-soluble Vitamin, 1, 25-dihydroxycholecalciferol (1, 25-(OH) D ) is a hydroxylated derivative of Vitamin D which is also its active form. It essentially regulates calcium homeostasis and plays a vital role in bone formation, skeletal development in chicks and formation of organic and inorganic layers of eggshell in layers.
Dynamic – α is an herbal blend of phytoconstituents which increase the bioavailability of Vitamin D. It contains hydroxylated metabolites of Vitamin D from plant origin and some amount of free and conjugated forms as glycosides.
The physiological functions of 1, 25(OH) D
As a calcium binding protein
Calcitriol is a biologically active form of Vitamin D that increases the intestinal absorption of calcium and phosphate. In the intestinal cells, calcitriol binds with a cytosolic receptor to form a calcitriol-receptor complex. This complex then approaches the nucleus and interacts with a speciﬁc DNA leading to the synthesis of a speciﬁc calcium-binding protein. This protein increases the calcium uptake by the intense and bone which subsequently inﬂuences the eggshell formation. The mechanism of action of calcitriol on the target issue (intense) is similar to the action of a steroid hormone.
Role in bone formation
In addition, Vitamin D has been linked to the viability of the chicken embryo. A speciﬁc active derivative of Vitamin D called 1, 25- dihydroxy Vitamin D has shown to stimulate the formation of cartilage in chick embryos. Likewise, 1, 25- dihydroxy Vitamin D also works with transforming growth factor-beta 3 to stimulate bone growth in chicken embryos. Since the skeleton is a major organ that is necessary for survival in vertebral species, the association of Vitamin D with the development of the skeleton in the preliminary stage of life demonstrates its cruciality in bone formation.
Laying hens have cancellous, cortical, and medullary bones that are used to supply calcium for eggshell formation. Speciﬁcally, the medullary bone serves as a calcium reservoir ready to release calcium at the onset of eggshell formation. Vitamin D induces bone collagen maturation which is important for bone strength and health. Hence Vitamin D is not only important for regulating bone turnover, but also for providing bone stabilization and ﬂexibility in the skeletal system.
Role in eggshell matrix formation
The eggshell is composed of the matrix proteins (osteopontin) that participate in crystallization during the formation of the calciﬁed issues and contribute to the biomechanical properties of the egg. Osteopontin (OPN) is part of an array of macromolecules synthesized and secreted by the cells adjacent to the mineralization front, that self-assemble outside the cell and direct crystal formation. The OPN meets the theoretical requirements for involvement in the mineralization process. The phosphorylated residues of acidic phosphoprotein have been shown to exist in the protein as reactive monoesters that are available for interaction with calcium ions. Thus, forming a matrix that consists, of an organic component like osteopontin and an inorganic component like calcium. Dynamic – Alpha stimulates transcription of the extracellular matrix phosphoprotein osteopontin (OPN), ultimately giving a beer eggshell matrix and quality.
Dynamic Alpha as Absorption Enhancers
Though Vitamin D is a fat-soluble Vitamin, the amount of fat with which it is ingested does not aﬀect its bioavailability. Even the feed matrix or composition has little eﬀect on the bioavailability of Vitamin D. Moreover, during the digestion process, the Vitamin D needs to be extracted from its feed or supplement matrix to be bioaccessible i.e. to become solubilized in micelles and available for absorption. Dynamic Alpha contains compounds that can form micelles that improve the absorption eﬃciency of liposoluble constituents including fat-soluble Vitamins.
Beneﬁts and Features
- Maintain Homeostasis of Ca: P in the body
- Increases bone density
- Helps in development and maintenance of bones, beak and feathers
- Helps to overcome lameness, bone developmental disorders and bone breakage
- Helps in preventing egg damage by increasing the shell thickness of eggs
- Improves Vitamin D content of the yolk
- Improves egg quality and quantity
- Improves growth and production performance