Avian coccidiosis is a deadly and debilitating infectious disease in poultry caused by obligate intestinal protozoan parasites belonging to the genus Eimeria. In general, these parasites damage the guts of the birds, leading to moderate clinical symptoms such as sick bird appearance, bloody stool, haemorrhage which ultimately results in intestinal lesions, enteritis, and even death. There are currently around 9 species of Eimeria identified from poultry, but each has a predilection site in the chicken digestive tract.
Eimeria primarily invades and resides in the lining of the caecum of exposed chickens. Infective sporozoites enter the caecal mucosa by penetrating villus epithelial cells, resulting in extensive destruction of the caecal epithelium,haemorrhagic faeces, reduction in body weight gain, and decrease in feed efficiency and eventually mortality which lead to serious economic consequences.
Current prophylaxis and therapy for coccidiosis comprise anticoccidial chemicals, vaccines, and natural products. Anticoccidial chemicals, coccidiocides, coccidiostats, and ionophores, have long been used as a mainstream strategy to control avian coccidiosis in modern poultry production. Although this strategy is cost-effective and successful, the presence of drug resistance and public demands for residue free meat has encouraged development of alternative control strategies.
Plants are a rich source of phytochemicals against coccidiosis. BIOCOCCIN is a combination of phytochemicals with diverse mechanism of action on multiple species of Eimeria. These active constituents suppress the developmental stages in the lifecycle of Eimeria by several mechanisms which are summarized below.
- Prevention of oocyst development
- Inhibition of sporulation
- Inhibition of the oocyst wall
- Destruction of sporozoites in caeca
- Stabilizing intestinal structure and decreasing inflammation
- Stimulation of immune response and modulation
- Safe and compatible with all the feed ingredients and vaccines
- Acts on all major species of Eimeria
- Reduces the number of coccidial to keep infection in check till immunity is established
- Reduces oocysts shedding
- Decreases intestinal inflammation
- Enhances immunity and antioxidant activity